Experimental Induction of Lyme Arthritis in Outbred Mice
نویسندگان
چکیده
منابع مشابه
Experimental Borrelia burgdorferi infection of outbred mice.
Infectivity of Borrelia burgdorferi strain 297 in normal outbred ddY mice was examined. Strain 297 was inoculated intraperitoneally in 3-week-old outbred ddY mice. B. burgdorferi was routinely cultured from the heart and urinary bladder 5 to 84 days postinoculation. The combined isolation rate from both heart and urinary bladder was significantly higher than the rate from spleen, kidney, liver,...
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We determined that sera obtained from hamsters infected with Borrelia burgdorferi could prevent the induction of Lyme arthritis. When irradiated hamsters were administered immune serum and subsequently challenged with B. burgdorferi, no evidence of infection was detected. Recipients failed to develop swelling of the hind paws, and no histopathologic changes were detected. In addition, B. burgdo...
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Experimental Lyme arthritis is an inflammatory arthritis caused by infection of mice with the spirochete, Borrelia burgdorferi. It recapitulates many of the disease parameters seen in human patients with Lyme arthritis, and thus serves as a model system for the investigation of disease pathogenesis. While much progress has been made in defining components of the immune response to Borrelia infe...
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These results support and extend the observations of Gharavi et al.' They provide further evidence that antidsDNA and anticardiolipin antibodies are to some extent discrete populations in the patients with principally IgGl and IgG3 anticardiolipin binding-that is, the principal subclasses of IgG anti-dsDNA, showed no DNA binding. These results also emphasise the heterogeneity of anticardiolipin...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1994
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1994.tb01774.x